Application

NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.

Biochem/physiol Actions

NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC₅₀ value >57 µM for PHGDH. NCT-503 has an IC₅₀ value of 2.5 µM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.

Packaging

5, 25 mg in glass bottle

Recommended products

The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here.

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	ITLPIAAGIQAGRA-UHFFFAOYSA-N
InChI	1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
Quality Level	100
SMILES string	CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Safety Data Sheet for SML1671-25MG

Cas Number

1914971-16-6

This product has met the following criteria to qualify for the following awards:

NCT-503 INACTIVE CONTROL

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